![]() Furthermorewe demonstrated that exogenous administrated melatonin is able to accumulate efficiently in the follicular fluid. In conclusion melatonin supplementation during ovarian stimulationin aged patients improve oocyte and embryo quality, increasing progesterone production and scavenging free radicals. Melatonin intrafollicular concentrations were significantly increased after melatonin treatment (213☓5 pg/mL versus 69☒3 pg/mL). Oxidative stress values, mature oocytes, embryo quality, pregnancy rates and implantation rates, intrafollicular concentration of melatonin and progesterone were measured.There were significant statistical differences comparing group A with group B in terms of mature oocytes (48.2% vs 35.0%), oxidative stress (CARR U)(190 ± 41 vs 388☖4), antioxidative capacity (AOCs) (1,76☐,4 vs 0,89☐,2), progesterone concentration in follicular fluid (10,4☑.1 ml vs 4,3☐,8 ml) and grade I embryos (45,7% vs 30,4%, p = 0.0045). 358infertile women aged over 40 underwent a shortdown-regulation protocol and were randomized into two groups: 178 patients who received 5 mg melatonin (group A) and 180 patients who did not received melatonin (group B). The aim of the present study was to evaluate the role of melatonin supplementation on the main IVF outcomes in aged patients underwent IVF. Journal of Pediatrics and Palliative Care.International Journal of Cancer and Oncology.International Journal of Neurology and Brain Disorders.Journal of Gynecology and Neonatal Biology.Investigative Dermatology and Venereology Research.Journal of Gastrointestinal Disorders and Liver function.Journal of Environment and Health Science.Journal of Marine Biology and Aquaculture.Journal of Medicinal Chemistry and Toxicology.Journal of Analytical, Bioanalytical and Separation Techniques.Journal of Nanotechnology and Materials Science.Journal of Bioinformatics, Proteomics and Imaging Analysis.Journal of Veterinary Science and Animal Welfare.International Journal of Food and Nutritional Science.Letters in Health and Biological Sciences.Journal of Cellular Immunology and Serum Biology.International Journal of Hematology and Therapy. ![]() ![]() Journal of Stem Cell and Regenerative Biology.Journal of Pediatrics and Palliative Care ISSN:2690-4810.Journal of Heart and Cardiology ISSN:2378-6914.International Journal of Cancer and Oncology ISSN:2377-0902.International Journal of Neurology and Brain Disorders ISSN:2377-1348.Journal of Diabetes and Obesity ISSN:2376-0494.Journal of Gynecology and Neonatal Biology ISSN:2380-5595.Journal of Dentistry and Oral Care ISSN:2379-1705.Investigative Dermatology and Venereology Research ISSN:2381-0858.Journal of Gastrointestinal Disorders and Liver function ISSN:2471-0601. ![]()
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